1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone CAS 7226-23-5

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1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone CAS 7226-23-5 Chemical Specification 

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone CAS 7226-23-5 Chemical Properties

Melting point -20°C
Boiling point 146°C44mmHg(lit.)
Density 1.06g/mL at 25°C(lit.)
Vapor pressure 0.5hPa(57°C)
Refractive index n20/D1.488(lit.)
Flash point 121°C
Storage conditions Storebelow+30°C.
SolubilityChemicalbookChloroform(Slightly),EthylAcetate(Slightly)
Form Liquid
Acidity coefficient (pKa)-0.65±0.20(Predicted)
ColorClearcolorlesstoslightlyyellow

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone CAS7226-23-5Application

N,N-dimethylpropenylurea (DMPU) for the preparation and structure of alkaline earth metal iodide phosphine oxide and urea complexes.

Non-polar solvent, extremely low toxicity, light and heat resistance, strong acid and alkali resistance, good solubility, can dissolve various organic, inorganic, macromolecules, etc. In pharmaceutical preparations, it can be added as an excipient to improve drug absorption speed and prolong effect time.

DMPU is a multifunctional aprotic polar solvent for N-alkylation of chiral primary amines, O-alkylation of aldoses and synthesis of poly(aryl ethers); it can effectively replace Chemicalbook's carcinogenic HMPA , acts as a cosolvent for highly reactive nucleophiles and bases; has high Z-selectivity in enolate formation; DMPU shows non-mutagenicity and safety.