2-Amino-5-fluorobenzoic acid CAS 446-08-2

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2-Amino-5-fluorobenzoic acid CAS 446-08-2 Chemical Specification 

2-Amino-5-fluorobenzoic acid CAS 446-08-2 Chemical Properties

Melting point 181-183°C (lit.)
Boiling point 223.67°C (roughestimate)
Density 1.3021 (estimate)
Storage conditions Keepindarkplace, Inertatmosphere, Roomtemperature
SolubilityDMSO(Slightly),Methanol(Slightly)
Acidity coefficient (pKa) 1.86±0.10 (Predicted)
Morphology FineCrystallinePowder
ColorLightyellowtolightbrown

2-Amino-5-fluorobenzoic acid CAS 446-08-2 Application

5-Fluoroanthranilic acid was synthesized from 2-methyl-4-fluoronitrobenzene as starting material. It uses Raney nickel as a catalyst and undergoes catalytic hydrogenation reduction with 2-methyl-4-fluoronitrobenzene at 50 °C. After filtering off the catalyst in Chemicalbook, the solvent is removed by distillation to obtain 5-fluoro-2-aminotoluene. , and then oxidized with potassium permanganate, acidified and filtered to obtain the crude product, and purified by alkali-soluble acid precipitation to obtain the purer final target product.