2-Amino-5-fluorobenzoic acid CAS 446-08-2 is a very important precursor for the synthesis of pharmaceuticals, herbicides, plant growth regulators and fungicides of the quinoline type.
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Product Name |
2-Amino-5-fluorobenzoic acid |
||
Formula |
C7H6FNO2 |
Molecular Weight |
155.13 |
CAS NO. |
446-08-2 |
Quantity |
500KG |
Items |
Specification |
Results |
Appearance |
Light yellow to light brown Fine Crystalline Powder |
Conforms |
Assay |
99% | 99.28% |
CONCLUSION |
The result conform with standard |
Melting point 181-183°C (lit.)
Boiling point 223.67°C (roughestimate)
Density 1.3021 (estimate)
Storage conditions Keepindarkplace, Inertatmosphere, Roomtemperature
SolubilityDMSO(Slightly),Methanol(Slightly)
Acidity coefficient (pKa) 1.86±0.10 (Predicted)
Morphology FineCrystallinePowder
ColorLightyellowtolightbrown
5-Fluoroanthranilic acid was synthesized from 2-methyl-4-fluoronitrobenzene as starting material. It uses Raney nickel as a catalyst and undergoes catalytic hydrogenation reduction with 2-methyl-4-fluoronitrobenzene at 50 °C. After filtering off the catalyst in Chemicalbook, the solvent is removed by distillation to obtain 5-fluoro-2-aminotoluene. , and then oxidized with potassium permanganate, acidified and filtered to obtain the crude product, and purified by alkali-soluble acid precipitation to obtain the purer final target product.