2-Chloro-5-nitropyridine CAS 4548-45-2

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2-Chloro-5-nitropyridine CAS 4548-45-2 Chemical Specification 

2-Chloro-5-nitropyridine CAS 4548-45-2 Chemical Properties

Melting point 105-108°C(lit.)
Boiling point 256.6±20.0°C(Predicted)
Density 1.6616 (roughestimate)
Refractive index 1.5500 (estimate)
Flash point 158°C
Storage conditions Keepindarkplace, Sealedindry, RoomTemperature acidity coefficient (pKa) -4.22±0.10 (Predicted)
MorphologyCrystallinePowder
ColorLightyellowtobeige
Solubilityinhotmethanol.Insolubleinwater.

2-Chloro-5-nitropyridine CAS 4548-45-2 Application

A preparation method of utilizing dichlorine monoxide to prepare 2-chloro-5-nitropyridine is to mix 3-nitropyridine and 1-3 times the amount of alkali in molar ratio, 1-2 times the amount of chloride salt and The solvent is mixed evenly, and cooled to -15°C to -10°C at a low temperature; after dissolving 2-3 times the molar ratio of dichloride monoxide in the solvent, it is dropped into the reaction mixture under full stirring, and maintained at -10°C. To 0 ° C, the dropwise addition was completed for 2 hours, the temperature was raised to room temperature and continued to stir for 2 hours until the reaction of the raw material 3-nitropyridine was complete, the reactant was poured into ice water, the organic layer was separated, the organic layer was collected, and the mass concentration of the organic layer was Wash with 5% hydrochloric acid once, wash with water once, dry with anhydrous magnesium sulfate, and evaporate the organic solvent under reduced pressure to obtain 2-chloro-5-nitropyridine.