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Product Name |
Cyclophosphamide |
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Formula |
C7H15Cl2N2O2P |
Molecular Weight |
261.09 |
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CAS NO. |
50-18-0 |
Quantity |
500KG |
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Items |
Specification |
Results |
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Appearance |
White powder |
Conforms |
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Assay |
99% | 99.1% |
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CONCLUSION |
The result conform with standard |
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Melting point: 41-45 ℃
Boiling point: 336.1 ± 52.0 ℃ (predicted)
Density 1.33 ± 0.1g/cm3 (predicted)
The storage conditions shall be kept below - 20 ° C in a marked position, inert atmosphere, freezer
Form: solid
Acidity coefficient (PKA) 2.84 ± 0.20 (predicted value)
Cyclophosphamide is one of the most commonly used alkylating agents for anti-tumor drugs. It is white crystal or crystalline powder at room temperature (i.e. liquefied when the crystal water is lost), and it is stable at room temperature. Soluble in water, but not very soluble. The aqueous solution is unstable, so it should be used in a short time after dissolution. Soluble in ethanol. It was first synthesized by Arnold and bourseaux in 1958. The synthesis of this compound and its derivatives was developed based on the structure and function of the previous chemobook anticancer drug. It is mainly used for tumor immunity. After entering the human body, it decomposes and releases chloroethyl phosphoramide (or phosphoramide nitrogen mustard) with strong alkylation effect under the catalysis of liver microsomal enzymes, which has cytotoxic effect on tumor cells and obvious inhibitory effect on a variety of tumors. In recent years, it has been used for the treatment of a variety of autoimmune diseases due to its immunosuppressive effect.
