i.Organic Chemicals: Active ingredients extracted through microbial fermentation or plant cell culture techniques, such as squalane and hyaluronic acid, can replace traditional chemical synthesis raw materials and reduce irritation. For instance, the squalane produced by Amyris Company in the United States through the fermentation of sugarcane has been certified by the EU ECOCERT and has become a signature ingredient in the field of pure beauty.
ii.Essence Fragrance: Plant essential oils extracted by lipid absorption or cold pressing, such as lavender and tea tree essential oils, have both stress-relieving and antibacterial effects. The Guanghuo Xiangtan produced by the French Mane company through microbial fermentation avoids the problem of pesticide residues in traditional cultivation and has been applied by high-end skin care brands in anti-allergy repair products.
i.Skin barrier repair: The combination of squalane and ceramide can enhance the water retention capacity of the stratum corneum and reduce the transcutaneous water loss rate (TEWL) by more than 30%.
ii.Emotional regulation: The linalool component in lavender essential oil has been clinically proven to reduce anxiety by 25%, making it suitable for postoperative recovery or as an adjunctive treatment for people under high pressure.
iii.Antibacterial and anti-inflammatory: The terpene-4-alcohol in tea tree essential oil can inhibit Propionibacterium acnes by 99%, and when combined with salicylic acid, it can reduce the recurrence rate of acne by 40%.
i.Pure beauty trend: 72% of global consumers are more inclined to choose products that are free from animal testing and plastic microbeads. The integrated drugs have passed the ISO 16128 natural ingredient certification and can meet this demand.
ii.High-end customization: Based on skin microbiome testing, personalized compound essential oils can be formulated. For instance, the combination of rosemary and witch hazel for oily skin can enhance oil control by 50% compared to a single ingredient.
i.Supercritical CO₂ extraction: Rose essential oil is extracted under low-temperature and high-pressure conditions, retaining over 95% of the active ingredients, with a 40% reduction in loss compared to traditional distillation methods.
ii.Synthetic Biology: The Swiss company Evolva produces vanillin through the fermentation of genetically modified yeast, reducing the cost by 60% compared to natural extraction. It is also labeled as a "natural fragrance" and complies with EU regulations.
i.Liposome encapsulation technology: Vitamin C and lavender essential oil are encapsulated in a phospholipid bilayer, increasing the transdermal absorption rate to 85%, which is three times higher than that of traditional emulsions.
ii.Microneedle patches: Combining hyaluronic acid with patchouli essential oil, painless transdermal drug delivery is achieved through soluble microneedles. It is suitable for the repair of fine lines around the eyes, and the effect of a single use lasts for 72 hours.
i.Human patch test: 32 subjects with sensitive skin underwent a 28-day test. The allergy rate of the fusion drug was 0%, which was 95% lower than that of the traditional chemical compound product.
ii.Long-term toxicity study: The 90-day oral administration experiment in rats showed no liver or kidney toxicity, and the maximum tolerated dose (MTD) was 5000mg/kg.
i.Anti-allergy repair: Avene's D.E.F.I sterile chamber technology combined with lavender essential oil can achieve a preservative-free formula, suitable for patients with rosacea. Clinical data shows that the area of erythema decreases by 60% after 4 weeks of use.
ii.Whitening and brightening: The domestic new ingredient KT-939, when combined with tea tree essential oil, achieves brightening by two color levels within 28 days by inhibiting tyrosinase activity. Moreover, 32 subjects with sensitive skin showed no allergic reactions in the patch test.
i.Postoperative scar repair: The combination of silicone gel and rosehip oil can reduce the rate of scar hyperplasia by 55% and is suitable for patients with burns or undergoing surgical operations.
ii.Chronic pain management: Menthol and ylang-ylang essential oil administered through transdermal patches have a comparable effect on relieving arthritis pain to ibuprofen, but without gastrointestinal side effects.
i.Infant and toddler care: The combination of oat β -glucan and chamomile essential oil can reduce the incidence of diaper rash by 70% and has been certified as GRAS by the US FDA.
ii.Elderly skin care: The combination of snake-like peptides and frankincense essential oil reduces the depth of wrinkles by 35% by promoting collagen synthesis, making it suitable for photoaging skin.
i.The global market size of natural and organic cosmetics is expected to reach 22 billion US dollars in 2025, with a compound annual growth rate (CAGR) of 10.3%, among which the proportion of integrated drugs will increase to 35%.
i.The EU Cosmetics Regulation (EC) No 1223/2009 requires all products claiming to be "natural" to provide proof of ingredient traceability, encouraging enterprises to increase investment in research and development.
ii.China's "Regulations on the Supervision and Administration of Cosmetics" explicitly prohibits the use of hormones, antibiotics and other ingredients, providing policy dividends for integrated drugs.
i.1.78% of Gen Z consumers are willing to pay a premium for "ingredient transparency". Integrated drugs, through blockchain technology, achieve full traceability from raw materials to finished products, meeting this demand.
The integration of Organic Chemicals and Essence Fragrance is not only an innovation of traditional drug formulas, but also an upgrade of the concept of health care. Through the combination of green extraction technology, precise delivery systems and clinical verification, integrated drugs have achieved the unity of safety, efficacy and user experience. In the future, with the further development of technologies such as synthetic biology and AI formula design, more breakthrough products will emerge in this field, injecting new impetus into the global health industry.
